Abstract： Objective： To observe the clinical effect of auricular point pressing with beans and point application with Chinese herbal medicine combined with routine medical measures on relieving lassitude in loin and legs caused by chronic renal failure(CRF). Methods： A total of 120 cases of CRF patients were randomly divided into the control group and the observation group，60 cases in each group. Both groups were given comprehensive treatment measures including controlling the blood pressure，blood glucose and blood lipid and reducing the proteinuria，as well as comprehensive nursing measures such as guidance on lifestyle adjustment and psychological nursing. The observation group was additionally given auricular point pressing with beans combined with point application with Chinese herbal medicine. Both groups were treated for four weeks. Before treatment and after four-week treatment，the degree of lassitude in loin and legs as well as the scores of fatigue and lack of strength，shortage of qi and disinclination to talk，clear nocturnal urine in large amounts，torpid intake and other related symptoms were evaluated. After four weeks of treatment，the satisfaction of patients on nursing work was evaluated by themselves. Results：After treatment，the scores of lassitude in loin and legs in the two groups were decreased when compared with those before treatment(P＜0.01)，and the score in the observation group was lower than that in the control group(P＜0.01). The scores of fatigue and lack of strength，shortage of qi and disinclination to talk，clear nocturnal urine in large amounts and torpid intake in the two groups were all decreased when compared with those before treatment(P＜ 0.01)，and the scores of the above four symptoms in the observation group were lower than those in the control group(P＜ 0.01). The nursing satisfaction in the observation group was higher than that in the control group(P＜0.05). Conclusion：Based on routine medical measures，the therapy of auricular point pressing with beans combined with point application with Chinese herbal medicine can significantly reduce the severity of lassitude in loin and legs of CRF patients， improve the related symptoms，and improve their quality of life.