Abstract：Objective：To discuss the therapy of Yaotuitong prescription combined with acupuncture in the treatment of chronic low back pain，and to observe its effect on the lumbar muscle function and clinical symptoms of patients. Methods：A total of 126 cases of patients with chronic low back pain were enrolled as the analysis objects， and divided into the observation group and the control group according to the random number table method，63 cases in each group. The control group was given acupuncture on the basis of routine treatment，and the observation group was additionally given Yaotuitong prescription based on the treatment of the control group. Before treatment and after four- week treatment，the changes in Chinese medicine syndrome scores [stabbing pain in the low back，pain relief with warmth，purple and dusky tongue/white and slippery fur，sunken，slow，and relaxed pulse]，difference in pain degree evaluated by score of Visual Analogue Scale (VAS) score，and score of Japanese Orthopedic Association(JOA) of low back pain were compared between the two groups. Before treatment and after four- week treatment， the changes in levels of inflammatory factors in serum [tumor necrosis factor-α(TNF-α)，interleukin-6(IL-6)，C-reactive protein(CRP)] were compared between the two groups. The clinical effect was recorded in the two groups. Results：The total clinical effective rate in the observation group(96.83%) was higher than that in the control group(87.30%)(P＜0.05). After four-week treatment，syndrome scores of stabbing pain in the low back， pain relief with warmth，purple and dusky tongue/white and slippery fur，sunken，slow，and relaxed pulse，as well as the total score in the two groups were decreased when compared with those before treatment，and the scores in the observation group were lower than those in the control group(P＜0.05). After four-week treatment，VAS scores in the two groups were lower than those before treatment，and the score in the observation group was lower than that in the control group(P＜0.05)； JOA scores in the two groups were higher than those before treatment，and the score in the observation group was higher than that in the control group(P＜0.05). After four-week treatment，levels of IL- 6，TNF- α，and CRP in serum in the two groups were lower than those before treatment，and the decrease in the observation group was bigger than that in the control group(P＜0.05). Conclusion： The therapy of Yaotuitong prescription combined with acupuncture has a significant curative effect on chronic low back pain， which can effectively improve clinical symptoms， reduce inflammatory indexes， relieve subjective pain sensation，and recover the lumbar function.