Abstract： Objective： To observe the clinical effect of Xingnaojing injection combined with piracetam for traumatic intracranial hemorrhage. Methods： A total of 68 cases of patients with traumatic intracranial hemorrhage were randomly divided into the control group and the treatment group，34 cases in each group. The control group was treated with piracetam sodium chloride injection，and the treatment group was additionally given Xingnaojing injection based on the treatment of the control group. After one month of treatment，the clinical effect in the two groups was compared. Before and after treatment， the cognitive function(MMSE scores)，activity of daily living(ADL scores) and neurological function(NIHSS scores) in the two groups were evaluated； the levels of tumor necrosis factor- α(TNF- α)， hypersensitive C- reactive protein(hs- CRP) and interleukin-10(IL-10) in serum in the two groups were detected；the incidence of adverse reactions in the two groups was observed. Results：The total effective rate was 100% in the treatment group and 88.24% in the control group，the difference being significant(P＜0.05). After treatment，the scores of MMSE and ADL in the two groups were increased when compared with those before treatment(P＜0.05)，and the above two scores in the treatment group were higher than those in the control group(P＜0.05). After treatment， NIHSS scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the score in the treatment group was lower than that in the control group(P＜0.05). After treatment， the levels of TNF- α， hs- CRP and IL- 10 in serum in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above indexes in the treatment group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 11.76% in the treatment group， and 8.82% in the control group， there being no significance in the difference(P＞0.05). Conclusion：Xingnaojing injection combined with piracetam for traumatic intracranial hemorrhage can improve the clinical effect，effectively protect the cognitive and neurological functions of patients，enhance their activity of daily living，improve the levels of inflammatory factors，and reduce the occurrence of sequela.