Abstract： Objective： To observe the clinical effect of warm needling therapy combined with Zhuifeng Tougu capsules based on routine western medicine for knee osteoarthritis(KOA). Methods：A total of 80 cases of KOA patients were divided into the control group and the observation group according to the random number table method，40 cases in each group. The control group was treated with celecoxib capsules and the observation group was additionally treated with warm needling therapy combined with Zhuifeng Tougu capsules based on the treatment in the control group. After 30- day treatment，the clinical effect in the two groups was observed and compared. Before and after treatment，the changes in symptom scores， knee joint function，pain degree of Visual Analogue Scale(VAS) scores and levels of inflammatory factors in the two groups were observed and compared. The symptom scores，knee joint function and pain degree in the two groups were followed up for one month. Results：The total effective rate was 90.0% in the observation group and 75.0% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of symptoms and VAS between the two groups(P＞0.05). After treatment，the scores of symptoms and VAS in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above two scores in the observation group were lower than those in the control group(P＜0.05)； after one- month follow- up， the scores of symptoms and VAS in the two groups were lower than those before treatment(P＜0.05)，and the above two scores in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of motor function scores in knee joint between the two groups(P＞0.05). After treatment，the motor function scores in knee joint in the two groups were increased when compared with those treatment(P＜0.05)，and the score in the observation group was higher than that in the control group(P＜0.05)； one month after treatment， the motor function scores in knee joint in the two groups were higher than those before treatment(P＜0.05)， and the score in the observation group was higher than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of inflammatory factors including tumor necrosis factor- α(TNF- α)， matrix metalloproteinase- 1(MMP- 1)，matrix metalloproteinase- 3(MMP- 3) and interleukin- 2(IL- 2) between the two groups(P＞ 0.05). After treatment， the levels of inflammatory factors in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above indexes in the observation group were lower than those in the control group(P＜ 0.05). Conclusion：Warm needling therapy combined with Zhuifeng Tougu capsules for KOA can improve curative effect and symptoms，relieve pain，restore knee joint function，and reduce the levels of inflammatory factors in synovial fluid.