Abstract：Objective：To discuss the pharmacodynamic effect of Miao nationality's medicine compound Jinqiaomai tang on chronic non-atrophic gastritis(CNG). Methods：A total of 60 rats were randomly divided into the normal group，the model group，the positive medicine group，and the compound Jinqiaomai tang groups of low-dose，medium-dose and high-dose (Group JQMⅠ，Group JQMⅡ，and Group JQM Ⅲ for short). Except for the normal group，in the other groups，CNG rat models were established by sodium deoxycholate，alcohol，and the method of abnormal starvation and overfeeding. Group JQMⅠ，Group JQMⅡ，and Group JQM Ⅲ were respectively given gastric perfusion of compound Jinqiaomai tang at the doses of 6.332，12.664，and 25.328 g/kg(crude medicine). The positive medicine group was given Wei-Tai 999 at the dose of 5.33 g/kg by gavage；the model group and the normal group were given gastric perfusion of distilled water of the same volume. The gastric juice，superoxide dismutase(SOD) and malondialdehyde(MDA) in gastric mucosa tissues，serum gastrin (GAS)，the activity of pepsin(PP)，and histopathology were observed in each group. Results：Compared with those in the normal group， the volume of gastric juice， free acid， total acidity， and the activity of SOD in the model group were decreased(P＜0.05)； pH value， the content of GAS， PP and MDA， as well as the scores of inflammation and lesions in gastric body，gastric antrum，and gastric angulus in the model group were increased(P＜0.05). Compared with those in the model group，the free acid，total acidity，and the activity of SOD in the positive medicine group were increased(P＜0.05)； the volume of gastric juice，pH value，the content of GAS，PP and MDA，as well as the scores of inflammation and lesions in gastric body， and gastric angulus in the positive medicine group were decreased(P＜0.05). Compared with those in the model group，pH value，the content of GAS and PP，as well as the scores of inflammation and lesions in gastric body，and gastric angulus in Group JQMⅠ，Group JQMⅡ，and Group JQM Ⅲ were decreased(P＜0.05)；the activity of SOD in Group JQM Ⅰ， and Group JQM Ⅲ was increased(P＜0.05)， and the volume of MDA was decreased(P＜0.05)； the volume of gastric juice，and total acidity in Group JQM Ⅱ were increased(P＜0.05)，and the content of MDA was decreased(P＜0.05)； the volume of gastric juice， free acid， and total acidity in Group JQM Ⅲ were increased(P＜0.05)， and the scores of inflammation in gastric body， gastric antrum， and gastric angulus were decreased(P＜0.05). Compared with those in the positive medicine group，the volume of gastric juice in Group JQMⅠ，Group JQMⅡ，and Group JQM Ⅲ was increased(P＜ 0.05)；the total acidity，GAS，and PP in Group JQMⅠwere decreased(P＜0.05)；the MDA contents in Group JQMⅠ，and Group JQM Ⅲ were decreased(P＜0.05)； the SOD activity in Group JQM Ⅱ was decreased(P＜0.05)； the scores of inflammation in gastric body，gastric antrum，and gastric angulus in Group JQM Ⅲ were decreased(P＜0.05). Compared with those in Group JQMⅠ，the volume of gastric juice，GAS，and PP in Group JQMⅡand Group JQM Ⅲ were increased(P＜ 0.05)；the SOD activity in Group JQMⅡwas decreased(P＜0.05). Compared with those in Group JQMⅡ，the total acidity， GAS，PP，and SOD activity in Group JQM Ⅲ were increased(P＜0.05)；the MDA content and the scores of inflammation in gastric body， gastric antrum， and gastric angulus in Group JQM Ⅲ were decreased(P＜0.05). Conclusion： Compound Jinqiaomai tang can effectively improve gastric mucosal lesion induced by compound factors in CNG rats，whose application in clinical treatment is supported by its pharmacodynamic result.