Abstract：Objective：To observe the curative effect of Shugan Lipi prescription combined with enema for chronic nonspecific ulcerative colitis with liver depression and spleen deficiency syndrome，and its effect on the levels of inflammatory factors， platelet， and erythrocyte sedimentation rate. Methods： A total of 86 cases of patients with chronic non- specific ulcerative colitis with liver depression and spleen deficiency syndrome were divided into the control group and the observation group according to the random number table method， 43 cases in each group. Both groups were given routine treatment methods. The control group was additionally given oral administration of mesalazine sustained- release tablets； the observation group was additionally treated with oral administration of Shugan Lipi prescription combined with enema based on the treatment on the control group. Both groups were treated for eight weeks. The curative effect was observed. The effect on the levels of inflammatory factors， blood platelet count(BPC)， and erythrocyte sedimentation rate(ESR) in serum were compared and analyzed. Results： After treatment， the inflammatory factors in the two groups were improved when compared with those before， and the levels of interleukin- 6(IL- 6) and tumor necrosis factor(TNF- α) in serum in the observation group were lower than those in the control group(P＜0.05)；the level of IL- 10 in serum was higher than that in the control group(P＜0.05). After treatment，the levels of BPC and ESR in the two groups were improved when compared with those before，and the two levels in the observation group were decreased，lower than those in the control group(P＜ 0.05). The total effective rate was 90.70% in the observation group， higher than that of 74.42% in the control group(χ 2= 3.957，P=0.047<0.05). Conclusion：For patients with chronic non-specific ulcerative colitis with liver depression and spleen deficiency syndrome，Shugan Lipi prescription combined with enema can inhibit inflammatory responses，and improve the coagulation mechanism，with good curative effect.