Abstract：Objective：To observe the clinical effect of Hanchuan Zupa granules in adjuvant therapy of infantile asthma at attacking stage. Methods： A total of 110 cases of children with syndrome of wind- cold fettering the lung were randomly divided into the control group and the observation group，55 cases in each group. Both groups were given terbutaline sulfate aerosol；for severe patients or patients with hypoxemia，they were given nasal cannula or oxygen mask；for severe patients and patients whose condition could not be controlled through spray inhalation，they were given prednisone acetate tablets and salbutamol sulfate injection. The course of both groups ranged from three to five days. The observation group was additionally given Hanchuan Zupa granules，and treated for seven days. Four weeks after seven-day treatment，the control of asthma was evaluated through Children's Asthma Control Test(C-ACT). Before treatment and after seven-day treatment， the lung function was measured；forced expiratory volume in one second(FEV1)，the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)， the percentage of peak expiratory flow in estimated value(PEF% )， the rate of diurnal variation in PEF and so on were recorded；the score of syndrome of wind-cold fettering the lung was evaluated. The clinical effect and the curative effect of Chinese medicine syndromes were compared between the two groups. The medication safety was evaluated. Results： After treatment， the clinical effect， the curative effect of Chinese medicine syndromes，and the control of asthma was better than that in the control group，differences being significant(P＜0.05). The indexes of FEV1，FEV1/FVC，and PEF% in the two groups were increased when compared with those before treatment，and the rate of diurnal variation in PEF was decreased，differences being significant(P＜0.01). The indexes of FEV1，FEV1/FVC， and PEF% in the observation group were higher than those in the control group，and the rate of diurnal variation in PEF was lower， differences being significant(P＜0.01). During treatment， no severe adverse reactions occurred in the two groups. According to the results of blood routine examination， electrocardiogram， and the examination of the lung and the kidney function，there was no adverse reactions evidently related to medicine or the use of Hanchuan Zupa granules. Conclusion： Based on routine therapy of modern medicine，the additional Hanchuan Zupa granules can further control the symptoms of infantile asthma at attacking stage，and has defined control effect of asthma and good medication safety.