Abstract： Objective： To summarize and analyze the administration rule of Prof. WU Liangcun in treating tumors of digestive system based on syndrome differentiation. Methods：From January 1，2017 to March 31，2019，79 patients with tumors of digestive system in Prof. Wu's outpatient clinic were collected， with 583 consultations in total. The clinical information of the patients was converted into the basic database of prescription. Descriptive analysis was conducted on the cumulative frequency，the category，the nature and flavor of Chinese herbs，and systematic cluster analysis and association rule analysis were conducted on the 50 herbs most frequently- used. Results：A total of 79 patients were treated with 199 kinds of herbs in all 583 consultations，and the cumulative frequency of used herbs was 10，753，among which the most frequently- used herbs were Fructus Citri Sarcodactylis， followed by Radix Paeoniae Alba， Poria， Rhizoma Dioscoreae， Radix et Rhizoma Glycyrrhizae and others. The most commonly- used herbal categories belonged to deficiencysupplementing medicine，followed by heat- clearing medicine，urination- promoting and dampness- percolating medicine， qi- regulating medicine and others. The nature of the most frequently- used herbs was neutral，and the flavor of the most frequently- used herbs was sweet. By cluster analysis， the Chinese herbs used were divided into sixteen categories， involving prescriptions like Sijunzi tang， etc. By the rule of two- medicine association， there were herbal combinations including Radix Pseudostellariae and Rhizoma Dioscoreae，Poria，Rhizoma Atractylodis Macrocephalae，respectively. By the rule of three- medicine association， there were medicinal combinations including deficiency- supplementing medicine plus urination- promoting and dampness- percolating medicine ， deficiency- supplementing medicine and exterior- releasing medicine，heat-clearing medicine and deficiency-supplementing medicine，digestion-promoting medicine and deficiencysupplementing medicine plus urination- promoting and dampness- percolating medicine ， qi- regulating medicine and deficiency- supplementing medicine. Conclusion： The differentiation and treatment of tumors of digestive system of Prof. WU were mainly to fortify the spleen and boost qi， accompanied by the methods of promoting urination and percolating dampness，resolving toxins and anti-cancer，promoting digestion and harmonizing the middle energizer. Prof. WU prefers to use sweet，bitter，acrid and neutral herbs to make medicinal combination in clinical medication.