Abstract：Objective：To observe the clinical effect of Daotan tang and Liujunzi tang in adjuvant chemotherapy of the lung cancer of spleen deficiency with phlegm- dampness type. Methods： A total of136 patients with the lung cancer of spleen deficiency with phlegm-dampness type were randomly divided into the control group and the study group，68 cases in each group. The control group was treated with DP chemotherapy， and the study group was additionally treated with Daotan Decoction and Liujunzi Decoction on the basis of the control group. The clinical effect， tumor control rate， and adverse reactions of the two groups were counted；the levels of immune function indexes(CD3 +，CD4 +，CD8 +，CD4 +/CD8 + ) and serum tumor markers [carcinoma embryonic antigen(CEA)， carbohydrate antigen 125(CA125)， cytokeratin 19 soluble fragment(CYFRA21-1)] were compared between the two groups. Results：The total effective rate was 94.12% in the study group，and 82.35% in the control group，the difference being significant(P＜0.05). The tumor control rate was 86.77% in the study group，and 72.06% in the control group，the difference being significant(P＜0.05). Before treatment，when compared the levels of CD3+ ， CD4+ ， CD8+ ， and CD4+/CD8+ between the two groups， there was no significance in the difference (P＞0.05). After treatment， the levels of CD3 + ， CD4 + ， and CD4 +/CD8 + in the study group were higher than those in the control group(P＜0.05)， and the level of CD8 + was lower(P＜0.05). After treatment， when compared the levels of CD3 + ， CD4+，CD8+，and CD4+/CD8+ before and after treatment in the control group，there was no significance in the difference (P＞0.05). After treatment，the levels of CEA，CA125 and CYFRA21- 1 in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the indexes in the study group were lower than those in the control group(P＜0.05). The incidence of the damage of the liver and kidney function，hemoglobin reduction，vomiting，diarrhea and abnormal alanine aminotransferase in the study group was lower than that in the control group(P＜0.05). Conclusion： The therapy of Daotan tang and Liujunzi tang has defined curative effect in adjuvant chemotherapy of the lung cancer of spleen deficiency with phlegm- dampness type. It can improve the immune function， decrease the levels of CEA， CA125， and CYFRA21-1 in serum，and reduce adverse reactions.