Abstract：Objective：To observe the effect of acupuncture method of regulating conception vessel and governor vessel combined with Dingkun pills on endometrial receptivity， prognostic pregnancy rate and hemorheology in patients with polycystic ovarian disease syndrome(PCOS) with infertility. Methods： A total of 120 cases of PCOS patients with infertility were selected and divided into the study group， the control group A， and the control group B according to the random number table method，40 cases in each group. The control group A was treated with routine ovulation induction；the control group B was treated with Dingkun pills based on the treatment of the control group A； the study group was additionally treated with acupuncture method of regulating conception vessel and governor vessel based on the treatment of the control group B. All groups were treated for three months. Before and after treatment，the endometrial thickness，the number of mature follicles， and menstrual cycle were compared among the three groups. The indexes of endometrial receptivity including glucose transporter 4(GLUT4) and integrin αvβ3，the indexes of serum sex hormones including follicle- stimulating hormone(FSH)， luteinizing hormone(LH) and prolactin(PRL)， as well as hemorheology indexes were compared among the three groups before and after treatment. During the six- month follow- up after treatment， the ovulation rate and the pregnancy rate in the three groups were counted. Results：After treatment，the endometrial thickness and the number of mature follicles in the three groups were increased when compared with those before treatment，and the two indexes in the study group were higher than those in the control group A and the control group B， differences being significant(P＜0.05). After treatment，the menstrual cycle in the three groups was shortened when compared with that before treatment，and the cycle in the study group was shorter than those in the control group A and the control group B，differences being significant (P＜0.05). After treatment， the positive expression levels of GLUT4 and integrin αvβ3 in the three groups were increased when compared with those before treatment，and the levels in the study group were higher than those in the control group A and the control group B，differences being significant(P＜0.05). After treatment，the levels of FSH，LH and PRL in serum in the three groups were decreased when compared with those before treatment，and the levels in the study group were lower than those in the control group A and the control group B，differences being significant(P＜0.05). After treatment，the plasma viscosity，whole blood low shear viscosity and whole blood high shear viscosity in the three groups were decreased when compared with those before treatment，and the indexes in the study group were lower than those in the control group A and the control group B，differences being significant(P＜0.05). After 6-month treatment，in the study group，the ovulation rate was 92.50%，and the pregnancy rate was 32.50%，both higher than those in the control group A and the control group B， differences being significant(P＜0.05). Conclusion：For PCOS patients with infertility，the therapy of acupuncture method of regulating conception vessel and governor vessel combined with Dingkun pills can increase endometrial thickness and the number of mature follicles，shorten menstrual cycle，improve endometrial receptivity，and hemorheology indexes，regulate the levels of sex hormones，and promote ovulation and pregnancy.