Abstract：Objective：To analyze the correlation between syndrome elements of Chinese medicine syndrome differentiation and etiology of hand-foot-mouth disease(HFMD) in children in Huizhou. Methods：A total of 2 250 cases of HFMD children were selected， including 1 847 mild cases and 403 severe cases. The frequency distribution of syndrome elements of Chinese medicine syndrome differentiation was counted；the enterovirus 71(EV71)，Coxsackievirus A 16(CoxA16)，CoxA6 and other enteroviruses(EV) were detected；the syndrome elements of Chinese medicine syndrome differentiation and the results of etiology in children with mild and severe HFMD were compared；the correlation between syndrome elements of Chinese medicine syndrome differentiation and etiology was analyzed. Results：The syndrome elements of Chinese medicine syndrome differentiation in 2 250 cases of HFMD children included wind- heat ， dampness- heat ， derangement of qi movement， internal wind， syncope， yin deficiency， yang and qi collapse， and qi deficiency， among which wind- heat (98.00% )， dampness- heat(86.98% )， derangement of qi movement(48.98% )， and yang and qi collapse(43.02% ) are relatively common. The results of etiology showed that EV71(47.69%)，CoxA16(25.29%) and CoxA6(14.76%) were common pathogens. The proportion of derangement of qi movement，internal wind，syncope，yin deficiency，yang and qi collapse， and qi deficiency in children with severe HFMD were higher than those in children with mild HFMD(P＜0.01)， and the proportion of wind-heat and dampness-heat were lower(P ＜ 0.01). The proportion of EV71 and more than two positive pathogens in children with severe HFMD were higher than those in children with mild HFMD(P＜0.01)，and the proportion of CoxA16，CoxA6 and other EV were lower(P＜0.01). There were positive correlations being found between syncope as well as yang and qi collapse and EV71 as well as more than two positive pathogens(P＜0.01)；the derangement of qi movement and more than two positive pathogens showed a positive correlation(P＜0.01). Conclusion：The syndrome elements of Chinese medicine syndrome differentiation of HFMD in children in Huizhou are commonly characterized by wind- heat，dampnessheat， derangement of qi movement and yang and qi collapse；the main pathogens are EV71，CoxA16 and CoxA6. Based on Chinese medicine syndrome differentiation and treatment for children with syncope and yang and qi collapse， specific treatments for viruses like EV71 should be given，with vigilance for infection with more than two pathogens.