Abstract：Objective：To observe the clinical effect of Danggui Tiaojing Yangxue mixture for diminished ovarian reserve. Methods：A total of 60 cases of patients with diminished ovarian reserve function of qi-blood deficiency type were randomly divided into the observation group and the control group，30 cases in each group. The observation group was treated with Danggui Tiaojing Yangxue mixture every morning and evening from the 5th day of menstruation， 100 mL each time， and stopped treatment on the 1st day of the next menstruation. The control group was given estradiol valerate tablets for 21 consecutive days from the 5th day of menstruation，1 mg each time，once a day；on the 11th day of taking estradiol valerate tablets，100 mg progesterone capsules were added into the treatment of the control group twice a day for 10 consecutive days. Both groups were treated for three courses， one menstrual cycle being a course. After three menstrual cycles， the Chinese medicine syndrome scores， follicle- stimulating hormone(FSH)， luteinizing hormone(LH)， estradiol(E2)， antimullerian hormone(AMH)， bilateral ovarian area， and antral follicle count(AFC) were observed in the two groups. Results： The total effective rate was 83.33% in the observation group，and 76.67% in the control group，there being no significance in the difference(P＞0.05). When compared with those before treatment， menstrual volume in the observation group was significantly increased，and Chinese medicine syndrome scores were significantly decreased(P＜0.01)；no significant change was found in menstrual volume and the scores in the control group before and after treatment(P＞0.05). After treatment，in the two groups，the levels of FSH and LH were significantly decreased，and AMH，ovarian area and AFC were significantly increased，differences being significant(P＜0.01)；no significant change was found in the comparison of E2 before and after treatment(P＞0.05). After treatment，when compared with those in the control group，in the observation group，menstrual volume was significantly increased， and Chinese medicine syndrome score was significantly decreased(P＜0.05). After treatment， when compared FSH， LH， E2， AMH， ovarian area， and AFC between the two groups， there was no significance in the difference(P＞0.05). The total incidence of adverse reactions was 6.67% in the observation group， and 20.0% in the control group， the difference being significant(P＜0.05). Conclusion： Danggui Tiaojing Yangxue mixture can significantly improve ovarian function of diminished ovarian reserve patients of qi- blood deficiency type，with few adverse reactions.