Abstract：Objective：To observe the effect of Yiqi Yangyin tang combined with chemotherapy for patients with advanced non-small cell lung cancer and its improving effect on quality of life. Methods：A total of 84 cases of patients diagnosed as advanced non- small cell lung cancer by surgery and histopathology were divided into the control group and the observation group according to the random number table method， 42 cases in each group. The control group was given simple chemotherapy with docetaxel combined with cisplatin，and the observation group was additionally given oral administration of Yiqi Yangyin tang based on the treatment of the control group. The changes in Chinese medicine syndrome scores before and after treatment and curative effect in the two groups were evaluated. Before and after treatment，the quality of life in the two groups was assessed by EORTC QLQ- C30，EORTC QLQ- LC 13 and Karnofsky Performance Score(KPS)，and the serum immunological indexes were detected. During treatment，the adverse reactions were recorded. Results：The total effective rate was 85.71% in the observation group，higher than that of 59.52% in the control group(P＜0.05). After treatment，the Chinese medicine syndrome scores in the two groups were significantly decreased when compared with those before treatment，and the score in the observation group was lower than that in the control group(P＜0.05). After treatment，the scores of quality of life in the two groups were increased when compared with those before treatment，and the score in the observation group was higher than that in the control group(P＜0.05). After treatment，the KPS scores in the two groups were increased when compared with those before treatment，and the score in the observation group was higher than that in the control group(P＜0.05). After treatment，the levels of CD3+ and CD4+ and the values of CD4+/CD8+ in serum in the two groups were increased when compared with those before treatment，and the increase in the observation group was more than that in the control group(P＜0.05). The incidences of reduction of white blood cell count， nausea， vomiting and diarrhea in the observation group were significantly fewer than those in the control group， the difference being significant(P＜0.05). Conclusion：During chemotherapy，the application of Yiqi Yangyin tang for patients with advanced non-small cell lung cancer can improve their curative effect，immune function and quality of life with fewer adverse reactions.