Abstract：Objective：To observe the curative effect of Shugan Jieyu Anshen tang for depression and its effect on sleep quality and neurotransmitter. Methods：A total of 200 cases of patients with depression were divided into the control group and the observation group according to the random number table method，100 cases in each group. Both groups were treated with routine treatment，and the observation group was additionally treated with oral administration of Shugan Jieyu Anshen tang. Both groups were treated for 40 days. The curative effect was observed， and the effect on sleep quality and neurotransmitter was analyzed. Results：After treatment，the scores of Pittsburgh Sleep Quality Index(PSQI) and Hamilton Depression Scale (HAMD) in the observation group were decreased and lower than those in the control group(P＜0.05). After treatment，the level of neurotransmitter in the observation group was increased and higher than that in the control group(P＜ 0.05). After treatment， the total effective rate was 92.00% in the observation group， higher than that of 74.00% in the control group (χ2=11.481，P=0.001<0.05). The incidence of adverse reactions was 2.00% in the observation group，lower than that of 8.00% in the control group (χ2=4.508，P=0.034<0.05). Conclusion：For patients with depression，Shugan Jieyu Anshen tang can improve their sleep quality and promote the release of neurotransmitter，with good curative effect.