Abstract：Objective：To observe the clinical effect of the therapy of Pingpitang combined with rabeprazole on chronic non-atrophic gastritis (CNAG) of spleen and stomach damp-heat type. Methods：A total of 114 CNAG patients of spleen and stomach damp-heat typewere divided into the observation group and the control group according to the random number table method，57 cases in each group.The control group was treated with rabeprazole，and the observation group was treated with Pingpitang based on the treatment of the control group；both groups were treated for four weeks. The clinical curative effect and Hp clearance ratein the two groups were recorded；before and after treatment，the changes in the scores of Chinese medicine syndromes such as distention and fullness in the stomach cavity and abdomen，dull pain in the stomach cavity， belching and sour regurgitation，poor appetite，nausea and vomiting as well as mental fatigue and lack of strength，and thelevels of serum epidermal growth factor (EGF)，nitric oxide (NO)，interleukin-6 (IL-6)，tumor necrosis factor-α(TNF-α) and interferon-γ(IFN-γ) in the two groups were compared. Results：The total effective rate was 96.49% in the observation group and 85.96% in the control group，the difference being significant(P＜0.05). After treatment，the scores of distention and fullness in the stomach cavity and abdomen， dull pain in the stomach cavity， belching and sour regurgitation， poor appetite，nausea and vomiting as well as mental fatigue and lack of strengthand the total scores in the two groups were lower than those before treatment(P＜0.05)，and the above scores in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of serum EGF，IL-6，TNF-α and IFN-γ in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of NOin the two groupswere increased(P＜0.05)； the improvement of the above indexes in the observation group was more significant than that in the control group(P＜0.05). The Hp clearance rate was 68.42% in the observation group and 49.12% in the control group，the difference being significant(P＜ 0.05). Conclusion： The therapy of Pingpitang combined with rabeprazole has a significant effect on CNAG of spleen and stomach damp-heat type，which can effectively improve the clinical symptoms of patients，reduce inflammatory damage， and improve the Hp clearance rate.