Abstract： Objective： To observe the clinical effect of Xingnaojing injection combined with rehabilitation nursing for Alzheimer disease(AD). Methods：A total of 60 cases of AD patients were enrolled in the control study，and were divided into the observation group and the control group according to the random number table method，30 cases in each group. The observation group was treated with Xingnaojing injection and rehabilitation nursing， and the control group was given rehabilitation nursing only. The scores of Mini-Mental State Examination(MMSE)，Alzheimer's Disease Assessment Scale Cognitive Subscale(ADAS-cog)，and Activity of Daily Living(ADL) were compared. Results：Before treatment，there was no significant difference being found in the comparison of MMSE score between the two groups(P＞0.05). The MMSE scores one month and three months after treatment in the observation group were higher than those in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of ADAS-cog score between the two groups(P＞0.05). The ADAS-cog scores one month and three months after treatment in the observation group were lower than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of ADL score between the two groups(P＞0.05). The ADL scores one month and three months after treatment in the observation group were lower than those in the control group(P＜0.05). Conclusion：The therapy of Xingnaojing injection combined with rehabilitation nursing for AD patients can significantly improve clinical symptoms，and delay the progression of disease.