Abstract： Objective： To observe the effect of auricular point application combined with comprehensive nursing intervention on patients with secretory otitis media(SOM). Methods：A total of 114 cases of SOM patients were selected and divided into the control group and the observation group according to the random number table method，57 cases in each group. The control group was given routine nursing intervention， and the observation group was given auricular point application combined with comprehensive nursing intervention. Before and after intervention，the changes in the scores of Self-Rating Depression Scale(SDS) and Self-Rating Anxiety Scale(SAS)，normal rates of eustachian tube function and air bone gap in the two groups were compared. The extinction time of earache and swelling in tympanic membrane as well as the disappearance time of middle ear effusion were observed. The scores of Kolcaba's General Comfort Questionnaire and SOM recognition as well as the satisfaction of patients were compared. Results：After intervention，the scores of SDS and SAS in the two groups were decreased when compared with those before intervention，and the scores in observation group were lower than those in the control group(P＜0.05). After intervention，the normal rate of eustachian tube function was 73.68% in the observation group，higher than that of 40.35% in the control group(P＜0.05). After intervention，the air-bone gaps in the two groups were decreased when compared with those before intervention，and the air-bone gap in the observation group was lower than that in the control group(P＜0.05). The extinction time of earache and swelling in tympanic membrane as well as the disappearance time of middle ear effusion in the observation group were shorter than those in the control group (P＜0.05). After intervention，the comfort level and SOM recognition score in the observation group were higher than those in the control group(P＜0.05)；the satisfaction of patients was 94.74% in the observation group，higher than that of 75.44% in the control group(P＜0.05). Conclusion： The therapy of auricular point application combined with comprehensive nursing intervention for SOM patients can improve their eustachian tube function，hearing function and mood disorders，promote their recovery，increase their illness perceptions，and enhance their comfort level and satisfaction.