益气复脉颗粒联合常规西药治疗慢性心力衰竭临床研究
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R541.6

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Clinical Study on Yiqi Fumai Prescription Combined with Routine Western Medicine for Chronic Heart Failure
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    摘要:

    目的:观察益气复脉颗粒联合常规西药治疗慢性心力衰竭(CHF) 的临床疗效。方法:将98 例CHF 患者随机分为观察组和对照组,各49 例。对照组给予常规西药厄贝沙坦片、硝酸异山梨酯片、地高辛片等治疗,观察组在对照组治疗的基础上加服益气复脉颗粒治疗,2 组连续治疗8 周。评估2 组临床疗效;比较2 组治疗前后左心室舒张末径(LVEDD)、收缩末径(LVESD)、左心室射血分数(LVEF) 水平;检测2 组治疗前后血清肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6) 水平,检测Bcl-2 蛋白、Bcl-2 mRNA 基因表达。结果:观察组总有效率为91.84%,对照组为77.55%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组LVESD、LVEDD 及血清TNF-α、IL-6 水平较治疗前降低(P<0.05),LVEF、血清Bcl-2 mRNA 及蛋白质表达水平较治疗前升高(P<0.05);且观察组以上各指标改善较对照组更显著(P<0.05)。结论:益气复脉颗粒联合常规西药治疗CHF,可有效改善慢性心衰患者心功能,调节炎症因子及Bcl-2 mRNA 基因表达水平,疗效优于单纯西药治疗。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Yiqi Fumai prescription combined with routine western medicine for chronic heart failure(CHF). Methods:A total of 98 cases of CHF patients were randomly divided into the observation group and the control group, 49 cases in each group. The control group was given routine western medicine including irbesartan tablets,isosorbide dinitrate tablets,and digoxin tablets;the observation group was additionally given the oral administration of Yiqi Fumai prescription based on the treatment of the control group. Both groups were continuously treated for 8 weeks. The clinical effect was evaluated in the two groups.Levels of left ventricular end- diastolic diameter(LVEDD),left ventricular end- systolic diameter(LVESD), and left ventricular ejection fraction(LVEF) before and after treatment were compared between the two groups. Levels of tumor necrosis factor- α(TNF- α) and interleukin- 6(IL- 6) in serum before and after treatment were detected in the two groups.Gene expression levels of protein and mRNA of Bcl-2 before and after treatment were detected in the two groups. Results:The total effective rate was 91.84% in the observation group,and 77.55% in the control group, the difference being significant(P<0.05). After treatment, levels of LVESD and LVEDD as well as levels of TNF-α and IL-6 in serum in the two groups were decreased when compared with those before treatment(P<0.05);LVEF levels and expression levels of mRNA and protein of serum Bcl- 2 in the two groups were increased when compared with those before treatment(P<0.05);the improvement of indexes above in the observation group was more significant than that in the control group(P<0.05). Conclusion: In the treatment of CHF, the combined therapy of Yiqi Fumai prescription and routine western medicine can effectively improve the heart function of patients with chronic heart failure, regulate inflammatory factors and gene expression level of mRNA of Bcl- 2, whose curative effect is better than that of simple western medicine.

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王玲.益气复脉颗粒联合常规西药治疗慢性心力衰竭临床研究[J].新中医,2021,53(5):55-58

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  • 在线发布日期: 2021-03-15
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