Abstract：Objective：To observe the effect of Shuxuening injection combined with routine western medicine treatment on neurological function defect and cognitive function of patients after acute cerebral infarction. Methods：A total of 93 cases of patients with acute cerebral infarction were randomly divided into the control group and the observation group，46 and 47 cases in each group respectively. The control group was given routine western medicine treatment， and the observation group was additionally given Shuxuening injection based on the treatment of the control group. Both groups received two courses，seven days being a course. After treatment，neurological function defect and cognitive function in the two groups were evaluated by National Institutes of Health Stroke Scale(NIHSS) and Mini- Mental State Examination(MMSE). Results： After treatment， grading of neurological function defect and cognitive function in the two groups were improved when compared with those before treatment， and the improvement in the observation group was better than that in the control group， differences being significant(P＜0.05). After treatment， NIHSS scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and MMSE scores were increased(P＜0.05)；the improvement of the two scores in the observation group was more significant than that in the control group(P＜0.05). Conclusion： The combined therapy of Shuxuening injection and routine western medicine treatment has significant improvement effect on neurological function defect and cognitive function.