Abstract： Objective： To explore the effect of traditional Chinese medicine Huoxuehuayu tang combined with rehabilitation exercise on neurological function and quality of life of patients with cerebral infarction. Method： 120 patients with cerebral infarction were divided into 2 groups(60 cases in each) according to the digital parity method. The control group received conventional treatment，and the observation group was treated with traditional Chinese medicine Huoxuehuayu tang combined with rehabilitation functional exercise based on the control group. The clinical efficacy， neurological function， motor function and quality of life were evaluated after continuous treatments for two months. Results：The total effective rate of treatment in the observation group(70.00%) was better than that in the control group(51.67%)(P＜0.05). Before treatment， there was no significant difference between the two groups of National Institutes of Health Stroke Scale(NIHSS) scores and Fugl- Meyer Function Scale(FMA score) (P＞0.05). The NIHSS score of the 2 groups decreased after treatment， and the observation group was lower than the control group(P＜0.05)；the FMA score of the 2 groups increased after treatment，and the observation group was higher than the control group(P＜0.05). Before treatment，there was no significant difference in the WHOQOL-BREF score between the two groups(P＞0.05)；the WHOQOL-BREF score of the two groups increased after treatment，and the observation group was higher than the control group(P＜0.05). Conclusion：The effect of Huoxue Huayu tang combined with rehabilitation exercise for patients with cerebral infarction is satisfactory，which can improve the curative effect，improve the neurological deficit，and has a positive effect on the recovery of motor function and the improvement of patients' quality of life.