Abstract：Objective：To observe the clinical effect of the application of Shugan Huazhuo tang based on routine western medicine intervention for nonalcoholic steatohepatitis(NASH) of liver depression and spleen deficiency type. Methods：A total of 116 cases of patients who were in accordance with the requirements were randomly divided into the control group and the observation group，59 cases in each group. Both groups were given the oral administration of polyene phosphatidylcholine capsules，diammonium glycyrrhizinate capsules and vitamin E soft capsules；the observation group was additionally treated with Shugan Huazhuo tang. Both groups were treated for three months. Before and after three-month treatment，the alanine aminotransferase(ALT)， aspartate transaminase(AST)， total cholesterol(TC) ， triglyceride(TG) ， high- density lipoprotein cholesterol(HDL- C) ， low density lipoprotein cholesterol(LDL- C) and fasting blood glucose(FBG)， fasting insulin(FINS) were detected；the indexes of insulin resistance index(IRI) were calculated；the abdominal CT was performed；the scores of liver depression and spleen deficiency syndrome were evaluated. The curative effect of Chinese medicine syndromes and abdominal CT in the two groups was compared. Results： After treatment， the curative effect of Chinese medicine syndromes and abdominal CT in the observation group was better than that in the control group(P＜0.05)；ALT and AST in the two groups were decreased when compared with those before treatment， and the above two indexes in the observation group were lower than those in the control group，differences being significant(P＜0.01). The levels of TC，TG and LDL-C in the two groups were decreased when compared with those before treatment， and the levels of HDL- C were increased， differences being significant(P＜0.01)；the levels of TC，TG and LDL-C in the observation group were lower than those in the control group， and the level of HDL- C was higher， differences being significant(P＜0.01). FBG， FINS and IR in the two groups were decreased when compared with those before treatment，and the above three indexes in the observation group were all lower than those in the control group， differences being significant(P＜0.01). Conclusion： Based on the comprehensive intervention of modern medicine， such as liver protection， enzyme reduction and anti- oxidation， the application of Shugan Huazhuo tang can further play the effect of liver protection and enzyme reduction，regulate the glucose and lipid metabolism，and improve IR with relatively definite curative effect.