康妇炎胶囊联合保妇康栓治疗湿热下注型慢性宫颈炎临床研究
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R711.32

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Clinical Study on Kangfuyan Capsules Combined with Baofukang Suppository for Chronic Cervicitis of Dampness-Heat Pouring Downward Type
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    摘要:

    目的:观察康妇炎胶囊联合保妇康栓治疗湿热下注型慢性宫颈炎的临床疗效。方法:将158 例湿热下注型慢性宫颈炎患者按随机数字表法分为对照组和研究组各79 例,对照组给予保妇康栓治疗,研究组给予康妇炎胶囊联合保妇康栓治疗。2 组均持续治疗2 个月。观察治疗期间2 组患者出现的药物不良反应,记录并比较治疗前与治疗2 个月后检测所得的血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6) 和白细胞介素-10(IL-10) 含量值,评价临床疗效,统计高危型人乳头瘤病毒(HPV) 转阴率及治疗结束后6 个月内宫颈炎的复发率。结果:治疗后,研究组疗效总有效率94.94%,高于对照组的83.54%,差异有统计学意义(P<0.05)。与治疗前比较,2 组血清TNF-α、IL-1 及IL-6 含量均下降,血清IL-10 含量均升高(P<0.05);研究组血清TNF-α、IL-1 及IL-6 含量均低于对照组,血清IL-10 含量高于对照组,差异均有统计学意义(P<0.05)。治疗结束后3 d 内,研究组HPV 转阴率88.24%,高于对照组的64.52%,差异有统计学意义(P<0.05)。治疗结束后6 个月内,研究组复发率8.00%,对照组复发率21.21%,2 组比较,差异有统计学意义(P<0.05)。2 组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:康妇炎胶囊联合保妇康栓治疗湿热下注型慢性宫颈炎可有效减轻炎症反应程度,促进高危型HPV 清除,缓解临床症状。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Kangfuyan capsules combined with Baofukang suppository for chronic cervicitis of dampness-heat pouring downward type. Methods:A total of 158 cases of patients with chronic cervicitis of dampness-heat pouring downward type were divided into the control group and the study group according to the random number table method,79 cases in each group. Both groups were continuously treated for two months. During treatment, adverse reactions were observed. The content of tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),interleukin-6(IL-6), and interleukin- 10(IL- 10) in serum was compared between the two groups before treatment and after treatment. The curative effect was evaluated. The negative rate of high- risk human papillomavirus(HPV)infection was counted. The recurrence rate of cervicitis during the first six months after treatment were counted. Results: After treatment, the total effective rate was 94.94% in the study group, higher than that of 83.54% in the control group, the difference being significant(P<0.05). The content of TNF-α,IL-1 and IL-6 in serum in the two groups was decreased when compared with that before treatment,and the content of IL-10 in serum was increased(P<0.05). The content of TNF-α,IL-1 and IL-6 in serum in the study group was lower than that in the control group,and the content of IL-10 in serum in the study group was higher; differences were significant(P<0.05). During the first three days after treatment, the negative rate of HPV was 88.24% in the study group,higher than that of 64.52% in the control group,the difference being significant(P<0.05). During the first six months after treatment,the recurrence rate was 8.00% in the study group,and 21.21% in the control group, the difference being significant(P<0.05). There was no significant difference being found in the comparison of total incidence of adverse reactions between the two groups(P>0.05). Conclusion:In the treatment of chronic cervicitis of dampness-heat pouring downward type, the therapy of Kangfuyan capsules combined with Baofukang suppository can effectively relieve inflammatory response and clinical symptoms,and promote the elimination of high-risk HPV.

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马雪莲.康妇炎胶囊联合保妇康栓治疗湿热下注型慢性宫颈炎临床研究[J].新中医,2021,53(5):116-119

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  • 在线发布日期: 2021-03-15
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