Abstract： Objective： To compare and analyze the clinical application value of Xiao'er Feike granules and ambroxol hydrochloride syrup in the treatment of chronic cough in children. Methods：A total of 200 children with chronic cough were divided into the study group and the control group，100 cases each，by digital parity. Based on the routine treatment，the control group was additionally treated with ambroxol hydrochloride syrup，and the study group was additionally treated with Xiao'er Feike granules. After two weeks of treatment， the clinical symptoms and signs in the two groups and the clinical effect were evaluated，and the immune function. Results：The total effective rate in the study group of 93.00% was higher than what was 67.00% in the control group，which was statistically significant(P＜0.05). Before treatment，the difference in the comparison of Chinese medicine syndrome scores between the two groups was no significant(P＞0.05). After treatment， the Chinese medicine syndrome scores in the two groups were decreased and the scores was statistically significant between the study group and the control group(P＜0.05). The cough relief time and cough disappearance time in the study group were earlier， what were statistically significant， than those in the control group(P＜0.05). There was no significant difference before treatment in the comparison of the levels of CD4+，CD8+，CD4+/CD8+ between all groups(P＞0.05). After treatment，the levels of CD8+ in the two groups were increased and the level of the study group was greater than that of the control group；the levels of CD4+ and CD4+/CD8+ were decreased and the level of the study group were greater，which was statistically significant，than those in the control group(P＜0.05). Conclusion：Compared with ambroxol hydrochloride syrup， Xiao'er Feike granules is more beneficial to improving the clinical effect， relieving the clinical symptoms and improving the immune resistance of children.