Abstract： Starting from the elaboration of academic thought of CHEN Zhiqiang's "treating syndrome and disease simultaneously"， this paper discusses the diagnosis and treatment strategy of apitherapy for bladder cancer patients after surgery. It is believed that apitherapy can treat the "syndrome" bladder cancer patients after surgery，and match the modern medical treatment concept，which is embodied in the following aspects：①bee needling therapy by selecting points based on syndrome differentiation can treat clinical “syndrome”； ②Inducing apoptosis of bladder cancer cells with melittin can treat "disease" in the aspect of modern medicine； ③ apitherapy reflects the academic thought of "three syndrome differentiations" under the strategy of "treating syndrome and disease simultaneously". It is suggested that it should be a feasible way to clinically carry out standard apitherapy based on syndrome differentiation for patients who had transurethral resection of bladder urothelial carcinoma.