Abstract： Objective： To observe the effect of oral administration of Chinese medicine decoction， retention enema combined with hot compress with moxa- salt bag for severe pancreatitis. Methods： A total of 256 cases of patients with severe pancreatitis were selected and divided into the control group and the observation group according to the random number table method，128 cases in each group. The control group was given routine western medicine，and the observation group was additionally treated with oral administration of Chinese medicine decoction，retention enema，and hot compress with moxa-salt bag. Both groups were given corresponding nursing. Before and after treatment，Chinese medicine syndrome scores，and the scores of Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ) were compared between the two groups. The remission time of abdominal pain， the recovery time of bowel sounds， the first defecation， hospitalization time， and adverse reactions were recorded in the two groups. A survey of satisfaction degree was carried out in the two groups. Results：Before treatment，when compared Chinese medicine syndrome scores and scores of APACHEⅡ between the two groups， there was no significance being found in the difference(P＞0.05). After treatment， Chinese medicine syndrome scores and scores of APACHEⅡin the two groups were significantly lower than those before treatment，and the two scores in the observation group were lower than those in the control group(P＜0.05). In the observation group， the remission time of abdominal pain，the recovery time of bowel sounds，and hospitalization time were shorter than those in the control group，and the first defecation was earlier(P＜0.05). The satisfaction rate was 98.44% in the observation group， higher than that of 89.84% in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of oral administration of Chinese medicine decoction， retention enema， and hot compress with moxa- salt bag has significant curative effect on severe pancreatitis. It will not increase the risk of adverse reactions，thus is easy to be accepted by patients.