Abstract: Objective: To study the effect of Ertong Shengzhang paste combined with moxibustion, exercise and adjustment of diet habit on improving the height of children. Methods:A total of 58 cases of children with comparably short stature were enrolled as study objects,and randomly divided into the study group and the control group,29 cases in each group. The study group was given Ertong Shengzhang paste combined with moxibustion, exercise and adjustment of diet habit,and the control group was given diet guidance. Blood serum index,the increase in height and growth rate,and the effective rate and adverse reactions were compared. Results: During the first three month of intervention, there was no significant difference being found in the comparison of the increase in height and growth rate between the two groups(P> 0.05);after six months of intervention,compared with those in the control group,the increase in height and growth rate in the study group were higher(P<0.05). Before intervention,there was no significant difference being found in the comparison of the levels of insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) between the two groups(P>0.05);after intervention,compared with those in the control group,the levels of IGF-1 and IGFBP-3 in the study group were both higher(P<0.05). The total effective rate was 79.31% in the control group and 96.55% in the study group,the difference being significant(P<0.05). Compared with that in the control group,the incidence of adverse reactions including hypothyroidism, edema and headache in the study group was lower(P<0.05). Conclusion: The application of Ertong Shengzhang paste combined with moxibustion, exercise and adjustment of diet habit for children with comparably short stature, can improve the increase in height and growth rate, and the curative rate, as well as reduce adverse reactions,with high safety.