Abstract： Chief Physician GUO Shaoju has rich experience in the prevention and treatment of gastroesophageal reflux disease，and proposed that its pathogenesis always lies in the root of liver depression and stomach weakness，along with qi counterflow and acid regurgitation as its branch. He put forward that its treatment is to treat the root and branch simultaneously，namely，to treat qi，acid，the liver and stomach simultaneously；only in this waycan the pathogenesis be closely stuck to and the condition be taken into account comprehensively，so as to improve the clinical effect. Based on the theory of the liver and stomach， it is proposed to treat gastroesophageal reflux disease by controling acid to calm the stomach， directing qi downward to strengthen the stomach， and soothing the liver to harmonize the stomach. In clinical practice，prescription should be combined with Xuanfu Daizhe tang，Fuzuojin pill，Sini powder，Wubei powder and Banxia Houpu tang，which needs to be modified according to the symptoms in order to tackle with the pathogenesis，whose clinical effect is significant.