Abstract：Objective：To observe the clinical effect of Shexiang Baoxin pills assisting routine western medicine for acute myocardial infarction(AMI) with qi stagnation and blood stasis syndrome. Methods：A total of 95 cases of AMI patients were selected and divided into the Shexiang Baoxin pills group and the routine group according to the random number table method，50 and 45 cases in each group respectively. The routine group was treated with routine western medicine，and the Shexiang Baoxin pills group was additionally treated with Shexiang Baoxin pills based on the treatment of the routine group. After eight-week treatment，the clinical effect and the improvement of symptoms in the two groups were compared；the heart function including left ventricular ejection fraction(LVEF)，left ventricular end-systolic volume(LVESV) and left ventricular end-diastolic volume(LVEDV) as well as the vascular endothelial function including nitric oxide(NO) and endothelin(ET) in the two groups were detected. Results：The total clinical effective rate was 96.00% in the Shexiang Baoxin pills group，higher than that of 75.56% in the routine group， the difference being significant(P＜0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the score in the Shexiang Baoxin pills group was lower than that in the routine group(P＜0.05). After treatment，LVEF levels in the two groups were increased when compared with those before treatment，and levels of LVESV and LVEDV were decreased(P＜ 0.05)； LVEF level in the Shexiang Baoxin pills group was higher than that in the routine group， and levels of LVESV and LVEDV were lower(P＜0.05). After treatment， NO levels in serum in the two groups were increased when compared with those before treatment，and ET levels in serum were decreased(P＜0.05)；NO level in the Shexiang Baoxin pills group was higher than that in the routine group，and ET level was lower(P＜0.05). Conclusion：Shexiang Baoxin pills assisting routine western medicine for AMI with qi stagnation and blood stasis syndrome has definite curative effect， which can effectively help patients to relieve clinical symptoms and significantly improve their heart function and vascular endothelial function.