Abstract：Objective：To discuss the effect of Tongxinluo capsules on Chinese medicine syndrome scores and vascular endothelial function in adjuvant treatment of patients with atherosclerotic cerebral infarction. Methods：A total of 160 cases of patients with atherosclerotic cerebral infarction were divided into the control group and the observation group according to the random number table method，80 cases in each group. The control group was given routine treatment，and the observation group was additionally given Tongxinluo capsules as adjunvant therapy based on the treatment of the control group. The clinical effect was compared between the two group. The changes in Chinese medicine syndrome scores， vascular endothelial function [serum endothelin(ET)，nitric oxide(NO)，von willebrand factor(vWF)，6- keto- prostaglandin F1α(6- KPGF1α)]， hemorrheology indexes [whole blood viscosity at low shear and high shear， plasma viscosity， hematocrit(HCT)， fibrinogen(FIB)]， and the incidence of adverse reactions were compared between the two groups. Results： The total effective rate was 90.00% in the observation group， higher than that of 72.50% in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P＞0.05). After treatment， Chinese medicine syndrome scores in the two groups were improved when compared with those before treatment，and the scores in the observation group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of vascular endothelial function between the two groups(P＞0.05). After treatment，levels of ET and vWF in serum in the observation group were lower than those in the control group，and levels of NO and 6-K-PGF1α were higher(P＜0.05). Before treatment，there was no significant difference being found in the comparison of hemorrheology indexes between the two groups(P＞0.05). After treatment，hemorrheology indexes in the two groups were improved when compared with those before treatment，and the indexes in the observation group were significantly lower than those in the control group(P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(χ 2=1.490，P=0.222). Conclusion： In adjuvant treatment of patients with atherosclerotic cerebral infarction， Tongxinluo capsules has significant curative effect，which can reduce their Chinese medicine syndrome scores，and improve vascular endothelial function and hemorrheology indexes.