Abstract： Objective： To observe the clinical effect of Fuzheng Huayu capsules combined with entecavir dispersible tablets for liver fibrosis in chronic hepatitis B. Methods：A total of 60 cases of patients with liver fibrosis in chronic hepatitis B were selected and divided into the control group and the observation group according to the remedy，30 cases in each group. The control group was treated with entecavir dispersible tablets， and the observation group was additionally treated with Fuzheng Huayu capsules based on the treatment of the control group. After six- month treatment，the clinical effect，liver function， four parameters of liver fibrosis， liver stiffness， Chinese medicine syndrome scores and incidence of adverse reactions in the two groups were compared. Results：After six-month treatment，the total effective rate was 93.3% in the observation group， higher than that of 73.3% in the control group， the difference being significant(P＜0.05). After treatment， the levels of alanine aminotransferase(ALT)， aspartate aminotransferase(AST)， total bilirubin(TBil) in the two groups were decreased when compared with those before treatment， and the levels in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the levels of hyaluronic acid(HA)， laminin(LN)，procollagen type Ⅲ(PCⅢ) and type Ⅳ collagen(Ⅳ-C) in the two groups were decreased when compared with those before treatment， and the levels in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment，liver stiffness measure(LSM) and Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，the LSM and Chinese medicine syndrome scores in the observation group were lower than that in the control group，differences being significant(P＜0.05). Conclusion：Fuzheng Huayu capsules combined with entecavir dispersible tablets has good clinical effect in treating liver fibrosis in chronic hepatitis B，which can improve the liver function and relieve liver fibrosis.