Abstract：Objective：To observe the effect of cycle therapy of Bushen Yangjing tang and Huoxue tang on hormones in serum and internal genital morphology in patients with polycystic ovary syndrome. Methods： A total of 98 patients with polycystic ovary syndrome(PCOS) were selected and divided into the control group and the observation group according to the random number table method，49 cases in each group. The control group was treated with clomiphene，and the observation group was additionally treated with cycle therapy of Bushen Yangjing tang and Huoxue tang based on the treatment of control group. The clinical effect after treatment was compared between the two groups， and the sex hormone levels， ovarian volume and endometrial thickness were measured before and after treatment. Results：The total effective rate was 89.80% in the observation group，higher than that of 73.47% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference in the comparison of ovarian volume and endometrial thickness between the two groups(P＞0.05). After treatment，the ovarian volume in the two groups was decreased and endometrial thickness was increased； the ovarian volume in the observation group was smaller than that in the control group， and the endometrial thickness was bigger than that in the control group；differences were significant(P＜0.05). Before treatment，there was no significant difference in the comparison of the levels of monocyte chemotactic protein- 1(MCP-1) and heat shock protein 70 (HSP70) between the two groups(P＞0.05). After treatment， the levels of MCP- 1 and HSP70 in the two groups were decreased when compared with those before treatment，and the levels of MCP-1 and HSP70 in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference in the comparison of hormone levels in serum between the two groups(P＞0.05). After treatment，the levels of follicle-stimulating hormone(FSH) and estradiol(E2) were increased，while levels of luteinizing hormone(LH) and testosterone(T) were decreased；and FSH and E2 levels in the observation group were higher than those in the control group，while LH and T levels were lower than those in the control group；differences were significant(P＜0.05). Conclusion：The cycle therapy of Bushen Yangjing tang and Huoxue tang can regulate the level of related factors in serum in PCOS patients，reduce the expression of MCP-1 and HSP70，and improve the morphology of internal genitals.