Abstract：Objective：To observe the clinical effect of Huoxue Sanfeng and Tiaohe Ganpi needling method on mild- tomoderate essential hypertension. Methods：A total of 120 cases of patients with essential hypertension were divided into the needling group and the medicine group according to the random number table method，60 cases in each group. The needling group was given Huoxue Sanfeng and Tiaohe Ganpi needling method to lower blood pressure，and the medicine group was given antihypertensive medicine. Before and after treatment as well as during one-month and three-month follow-up，24-h ambulatory blood pressure monitoring was carried out in the two groups；changes in mean value of blood pressure，blood pressure variability，load value of day- night blood pressure，and smoothness index were observed in the two groups. The standard- reaching rates of blood pressure in both groups were compared. Results：After treatment as well as during onemonth and three-month follow-up，24-h mean value of blood pressure，variability of blood pressure，load value of daynight blood pressure， and smoothness index in the two groups were better than those before treatment and those in the medicine group at the same period(P＜0.05). After treatment， 24- h mean value of blood pressure， variability of blood pressure， load value of day- night blood pressure， and smoothness index in the medicine group were better than those before treatment(P＜0.05)；during one- month and three- month follow- up，when compared indexes of 24- h ambulatory blood pressure monitoring in the medicine group with those before treatment， there were no significant differences being found(P＞0.05). After treatment as well as during one- month and three- month follow- up，the standard- reaching rates of blood pressure in the needling group were 59.65% ， 38.60% ， and 31.58% respectively， better than those of 41.07% ， 10.71%，and 5.36% in the medicine group respectively(P＜0.05). Conclusion：Huoxue Sanfeng and Tiaohe Ganpi needling method has sustainable and stable antihypertensive effect on mild-to-moderate essential hypertension，which is better than that of medicine treatment.