温阳益气利水方联合常规西药治疗慢性心力衰竭心肾阳虚证临床研究
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R541.6

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Clinical Study on Wenyang Yiqi Lishui Prescription Combined with Routine Western Medicine for Chronic Heart Failure with Heart-Kidney Yang Deficiency Syndrome
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    摘要:

    目的:观察温阳益气利水方联合常规西药治疗慢性心力衰竭(CHF)心肾阳虚证的临床疗效。方法:选取 93 例 CHF心肾阳虚证患者,按随机数字表法分为研究组 47 例和对照组 46 例。对照组给予常规西药治疗,研究组在对照组基础上加服温阳 益气利水方,2 组均连续治疗 4 周。比较 2 组中医证候疗效及治疗前后中医证候积分、血清氨基末端脑钠尿肽(NT-proBNP)水 平、左室射血分数(LVEF)、左室舒张末期直径(LVEDD)。结果:经秩和检验,研究组中医证候疗效优于对照组,差异有统计学意义 (P<0.05)。治疗后,2 组中医证候积分均较治疗前降低,研究组中医证候积分低于对照组,差异均有统计学意义 (P< 0.05)。治疗后,2 组 NT-proBNP 水平均较治疗前降低,LVEF 均较治疗前升高,LVEDD 均较治疗前缩小,差异均有统计学意义(P<0.05);研究组 NT-proBNP 水平低于对照组,LVEF 高于对照组,LVEDD 小于对照组,差异均有统计学意义(P<0.05)。结 论:温阳益气利水方联合常规西药治疗 CHF 心肾阳虚证,可以提高中医证候疗效,降低血清 NT-proBNP 水平,增强患者心功能。

    Abstract:

    Abstract:Objective: To observe the clinical effect of Wenyang Yiqi Lishui prescription combined with routine western medicine for chronic heart failure(CHF) with heart- kidney yang deficiency syndrome. Methods:A total of 93 cases of CHF patients with heart-kidney yang deficiency syndrome were divided into the study group and the control group according to the random number table method, 47 and 46 cases in each group respectively. The control group was treated with routine western medicine, and the study group was additionally treated with Wenyang Yiqi Lishui prescription based on the treatment of the control group. Both groups were continuously treated for four weeks. The curative effect of Chinese medicine syndrom was compared between the two groups. Chinese medicine syndrome scores,levels of N- terminal-pro hormone BNP(NT-proBNP) in serum,left ventricular ejection fraction(LVEF),and left ventricular end diastolic diameter(LVEDD) before and after treatment were compared in the two groups. Results:The curative effect of Chinese medicine syndrome in the study group was better than that in the control group,the difference being significant(P<0.05). After treatment,the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the study group was lower than that in the control group,differences being significant(P<0.05). After treatment,the levels of NT- proBNP in the two groups were decreased when compared with those before treatment;the levels of LVEF were increased;LVEDD was shortened;differences being significant(P<0.05). After treatment,when compared with those in the control group,in the study group,the level of NT-proBNP was lower,LVEF higher,and LVEDD smaller,differences being significant(P<0.05). Conclusion:In the treatment of CHF with heart-kidney yang deficiency syndrome,the therapy of Wenyang Yiqi Lishui prescription combined with routine western medicine can improve the curative effect of Chinese medicine syndrom,reduce level of NT-proBNP in serum,and strengthen the heart function.

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康彦同.温阳益气利水方联合常规西药治疗慢性心力衰竭心肾阳虚证临床研究[J].新中医,2021,53(7):51-54

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  • 在线发布日期: 2021-04-08
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