Abstract：Objective：To observe the effect of Kangfuyan capsules combined with metronidazole and ceftriaxone sodium for chronic pelvic inflammatory disease with dampness- heat accumulation syndrome. Methods： A total of 90 cases of patients with chronic pelvic inflammatory disease with dampness- heat accumulation syndrome were selected，and were divided into the study group and the control group according to the random number table method，45 cases in each group. Both groups were given metronidazole and sodium chloride injection and injection of ceftriaxone sodium，and the study group was additionally given Kangfuyan capsules. Both groups were continuously treated for two courses， one week being a course. The clinical effect after treatment and the incidence of adverse reactions during treatment were statistically analyzed in the two groups. Changes in inflammatory factors in serum， namely interleukin- 1(IL- 1)， interleukin- 2(IL- 2)， and hypersensitivity C-reactive protein(hs-CRP) before and after treatment were observed. Scores of Visual Analogue Scale(VAS) of pain before treatment as well as after one course and two courses were compared between the two groups. Results：After two courses，the total effective rate was 97.78% in the study group，higher than that of 82.22% in the control group，the difference being significant(P＜0.05). The levels of IL-1 and hs-CRP in the two groups were decreased when compared with those before treatment，and the levels of IL-2 were increased，differences being significant(P＜0.01)；the levels of IL-1 and hs-CRP in the study group were lower than those in the control group，and the level of IL-2 was higher than that in the control group，differences being significant(P＜0.01). Compared with those in the same group before treatment，scores of VAS of pain in the two groups were decreased after one course and two courses(P＜0.01). Compared with those in the same group after one course， scores of VAS of pain in the two groups were decreased after two courses(P＜0.01). After one course and two courses，scores of VAS of pain in the study group were lower than those in the control group(P＜0.01). The incidence of adverse reactions in the study group was lower than that in the control group，but there was no significance being found in the difference(P＞0.05). Conclusion：In the treatment of patients with chronic pelvic inflammatory disease with dampness- heat accumulation syndrome，the therapy of Kangfuyan capsules combined with metronidazole and ceftriaxone sodium has defined clinical effect，which can effectively relieve inflammatory response of body and pain with good safety.