Abstract： Objective： To observe the clinical effect of Jiedu lotion and Kuiyang lotion combined with routine western medicine for wound of diabetic foot ulcers. Methods：A total of 80 cases of patients with diabetic foot ulcers were selected and divided into the control group and the observation group according to the random number table method，40 cases in each group. Both groups were given treatment of wound，anti-infection，down- regulation of blood glucose，and other routine western medicine treatments；the observation group was additionally given Jiedu lotion to patients with redness and swelling as well as heat pain of wound，and Kuiyang lotion to patients with insignificant redness and swelling as well as heat pain of wound. Both groups were treated for four weeks. The clinical effect was observed in the two groups. The first appearance time of granulation tissue and the healing time of wound were recorded in the two groups. The changes in wound area before and after treatment were recorded in the two groups. Diabetes-specific Quality of Life Scale(DSQL) was applied to evaluating quality of life before and after treatment. Results：The total effective rate was 90.00% in the observation group，and 70.00% in the control group，the difference being significant(P＜0.05). After treatment，ulcer area in the two groups was decreased when compared with that before treatment(P＜0.05)， and the area in the observation group was smaller than that in the control group(P＜0.05). After treatment，the first appearance time of granulation tissue and the healing time of wound in the observation group were shorter than those in the control group， differences being significant(P＜0.05). After treatment， scores of psychology/mind，social relation，physical function，and influence of treatment of DSQL in the two groups were decreased when compared with those before treatment(P＜0.05)，and each score in the observation group was lower than that in the control group(P＜0.05). No significant adverse reactions occurred in the two groups. Conclusion：In the treatment of diabetic foot ulcers，the therapy of Jiedu lotion and Kuiyang lotion combined with routine western medicine can promote growth of granulation tissue，shorten the healing time of wound，and improve quality of life with significant clinical effect.