Abstract： Objective： To observe the clinical effect of Jiuwei Shuangjie oral liquid in adjuvant therapy of supperative tonsillitis of children. Methods： A total of 109 cases of children with supperative tonsillitis were divided into two groups according to random number table method. The control group(54 cases) was treated with amoxicillin and clavulanate potassium for suspension， and the observation group(55 cases) was additionally treated with Jiuwei Shuangjie oral liquid based on the treatment of the control group. After treatment， the disappearance time of tonsil redness and swelling， purulent secretion，sore throat，fever and cough after treatment were compared between the two groups；the recovery time of deglutition function and level of white blood cells were compared between the two groups. The hospitalization time and changes in levels of inflammatory factors before and after treatment were compared between the two groups. Results： After treatment，the disappearance time of tonsil redness and swelling and purulent secretion，as well as the recovery time of deglutition function in the observation group were significantly shorter than those in the control group，the difference being significant(P＜0.05). After treatment，the disappearance time of sore throat，fever and cough，the recovery time of white blood cells and hospitalization time in the observation group were significantly shorter than those in the control group， differences being significant(P＜0.05). After treatment， levels of tumor necrosis factor- α(TNF- α)， interleukin- 6(IL- 6)， interleukin-8(IL-8) ， hypersensitive C-reactive protein(hs-CRP) in serum in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and each level in the observation group was lower than that in the control group(P＜0.05). Conclusion： Jiuwei Shuangjie oral liquid has significant clinical effect in adjuvant therapy of supperative tonsillitis of children，which can effectively relieve tonsil redness and swelling，purulence，sore throat，fever， and other clinical symptoms，and reduce levels of inflammatory factors.