Abstract：Objective：To observe the clinical effect of Hanchuan Zupa granules combined with routine western medicine for bronchial asthma in children. Methods：A total of 98 cases of children with bronchial asthma of wind-cold and phlegmdampness type were selected and divided into the observation group and the control group according to the random number table method， 50 and 48 cases in each group respectively. After admission， both groups were given routine basic treatment；the control group was given ventolin aerosol inhalation，and the observation group was additionally treated with Hanchuan Zupa granules based on the treatment of the control group. Both groups were treated for seven days. The clinical effect，disappearance time of symptoms as well as the improvement of levels of serum inflammatory factors and indexes of lung function in the two groups were compared. Results：The total effective rate was 86.00% in the observation group and 66.67% in the control group， the difference being significant(P＜0.05). The disappearance time of coughing， wheezing， wheezing rales and dyspnea in the observation group was shorter than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of interleukin- 4(IL-4) and tumor necrosis factor-α(TNF-α) between the two groups(P＞0.05). After treatment，the levels of IL-4 and TNF-α in the two groups were decreased when compared with those before treatment，and the levels in the observation group were lower than those in the control group，differences being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of lung function indexes between the two groups(P＞0.05). After treatment，the forced vital capacity(FVC)， the peak expiratory flow rate(PEF) and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC) in the two groups were significantly increased when compared with those before treatment(P＜0.05)，and the increase in the observation group was significantly higher than that in the control group(P＜0.05). Conclusion：The therapy of Hanchuan Zupa granules combined with western medicine has significant clinical effect in treating children with bronchial asthma of wind-cold and phlegm- dampness type， which can effectively promote the remission of symptoms， inhibit the respiratory tract inflammation and improve the lung function.