Abstract： Objective： To observe the clinical effect of Qiangli Dingxuan capsules combined with betahistine mesilate tablets for vertigo. Methods：A total of 88 cases patients with vertigo were divided into the observation group and the control group according to the random number table method，44 cases in each group. Both groups were given nursing intervention； the control group was given betahistine mesilate tablets，and the observation group was additionally given Qiangli Dingxuan capsules based on the treatment of the control group. The clinical effect was compared between the two groups. Hemodynamics indexes as well as levels of human calcitonin gene-related peptide(CGRP) and endothelin-1(ET-1) in serum before and after treatment were detected. The incidence of adverse reactions was observed. Results：The total effective rate was 95.45% in the observation group， higher than that of 77.27% in the control group， the difference being significant (P＜0.05). Before treatment，when compared blood flow velocity of basilar artery(BA)，right vertebral artery(RVA)，and left vertebral artery(LVA) between the two groups，there was no significance in the difference(P＞0.05). After treatment，blood flow velocity of basilar artery(BA)，right vertebral artery(RVA)，and left vertebral artery(LVA) in the two groups was increased when compared with that before treatment(P＜0.05)，and blood flow velocity of the arteries above in the observation group was higher than that in the control group(P＜0.05). After treatment，levels of CGRP in the two groups were increased when compared with those before treatment，and levels of ET-1 were decreased(P＜0.05)；level of CGRP in the observation group was higher than that in the control group，and level of ET-1 was lower(P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＞0.05). Conclusion： In the treatment of vertigo，the therapy of Qiangli Dingxuan capsules combined with betahistine mesilate tablets can effectively relieve clinical symptoms like dizziness，and improve hemodynamics indexes，with significant curative effect.