Abstract：Objective：To observe the effect of the therapy of emotional nursing combined with point application on bad mood and quality of life in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD). Methods：A total of 86 patients with acute exacerbation of COPD were divided into the control group and the observation group according to random number table method，43 cases in each group. The control group was given routine nursing，and the observation group was additionally given emotional nursing combined with point application based on the treatment of the control group. The scores of Self-Rating Anxiety Scale(SAS)，Self-Rating Depression Scale(SDS) and St.George's Respiratory Questionnaire (SGRQ) before and after nursing were compared between the two groups. Results：Before nursing，there was no significant difference in the comparison of SAS and SDS scores between the two groups(P＞0.05). After nursing，SAS and SDS scores in the two groups were lower than those before nursing，and SAS and SDS scores in the observation group were lower than those in the control group，differences being significant(P＜0.05). Before nursing，there was no significant difference in the comparison of each score of SGRQ(P＞0.05). After nursing，each score of SGRQ was higher than that before nursing，and each in the observation group was higher than that in the control group，differences being significant(P＜0.05). Conclusion： The therapy of emotional nursing combined with point application can improve the quality of life of patients with acute exacerbation of COPD，relieve their anxiety and depression.