Abstract： Objective： To discuss the nursing effect of children tuina combined with medicine atomization for chronic persistent bronchial asthma in children. Methods：A total of 62 cases of children with chronic persistent bronchial asthma were selected as the observation object and randomly divided into the control group and the combination group，31 cases in each group. The control group was treated with medication atomization，and the combination group was additionally treated with children tuina based on the treatment of the control group. Before and after intervention， the expression level of inflammatory factors and the scores of clinical symptoms were compared between the two groups. The effective rate in the two groups was counted. Results：The combination group had better curative effect than the control group，with the total effective rate 10% higher than that of the control group，the difference being significant(P＜0.05). Before intervention，there was no significant difference being found in the comparison of scores of clinical symptoms between the two groups(P＞0.05). After intervention，scores of daytime symptoms and nighttime symptoms in the two groups were improved in varied degree； the two scores in the combination group were lower，and each score was close to normal and better than that in the control group，the difference being significant(P＜0.05). Before intervention，there was no significant difference being found in the comparison of inflammatory factors between the two groups(P＞0.05). After intervention，inflammatory factors in the two groups were improved in varied degree；in the combination group，the level of interleukin- 2(IL-2) was higher，and the levels of transforming growth factor-β1(TGF-β1)，interleukin-4(IL-4) and interleukin-17(IL-17) were lower；each index in the combination group was close to normal and better than that in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of children tuina combined with medicine atomization has significant clinical effect in the treatment of children with chronic persistent bronchial asthma， which can significantly improve their clinical symptoms， enhance immune function，and promote recovery.