Abstract： Objective： To study and analyze the effect of Chinese medicine characteristic nursing combined with behavioral change theory on negative emotions，compliance behavior and quality of life in senile patients with coronary heart disease. Methods：A total of 80 cases of senile patients with coronary heart disease were divided into the control group and the study group，40 cases in each group. In terms of nursing，the control group was given routine nursing，and the study group was additionally treated with Chinese medicine characteristic nursing combined with behavioral change theory based on routine nursing. Before and after intervention，the changes in negative emotions，compliance behavior and quality of life in the two groups were compared. Results：Before nursing，there was no significant difference being found in the comparisons of scores of Self- rating Depressing Scale(SDS) and Self- rating Anxiety Scale(SAS) between the two groups(P＞0.05). After nursing，the scores of SAS and SDS in the two groups were decreased，and the decrease in the study group was more than that in the control group， the difference being significant(P＜0.05). After nursing intervention， the score of compliance behavior in the study group was higher than that in the control group， the difference being significant(P＜0.05). Before nursing， there was no significant difference being found in the comparisons of scores of quality of life between the two groups(P＞0.05). After nursing intervention，the scores of quality of life in the two groups were increased，and the increase in the study group was more than that in the control group，the difference being significant(P＜0.05). Conclusion：Chinese medicine characteristic nursing combined with behavioral change theory helps patients improve negative emotions to actively overcome the disease，compliance behavior to cooperation with treatment，and quality of life.