Abstract： Objective： ToobservethecurativeeffectofmodifiedHuangqiGuizhiWuwutangonpatientswith hypoparathyroidismaftertotalthyroidectomy. Methods：Atotalof 60 casesofpatientscomplicatedwithhypoparathyroidism aftertotalthyroidectomywereselectedanddividedintotheobservationgroupandthecontrolgroupaccordingtotherandom numbertablemethod，30 casesineachgroup.Bothgroupsweretreatedwithpreventivecalciumsupplementaftersurgery.Onthe 3rd dayaftersurgery，thecontrolgroupwasgiventheoraladministrationofmedicineforcalciumsupplement，andthe observationgroupwasadditionallygiventheoraladministrationofmodifiedHuangqiGuizhiWuwutangbasedonthe treatmentofthecontrolgroup.Theclinicaleffectwascomparedbetweenthetwogroups.Thevaluesofparathyroidhormone (PTH)andcalciuminserumatdifferenttimepointsaftersurgeryweredetected. Results：Thetotaleffectiveratewas 93.3% intheobservationgroup，higherthanthatof 70.0%inthecontrolgroup，thedifferencebeingsignificant(P＜0.05).When comparedlevelsofPTHandcalciuminserumbetweenthetwogroupsbeforetreatmentaswellasonthe 1st，3rd，and 5th daysaftersurgery，therewasnosignificanceinthedifference(P＞0.05).Onthe 9th，15th，and 21stdaysaftersurgery，levels ofPTHandcalciuminserumintheobservationgroupweresignificantlyhigherthanthoseinthecontrolgroup，differences beingsignificant(P＜0.05). Conclusion： ModifiedHuangqiGuizhiWuwutangcanrelieveischemia-reperfusioninjuryof parathyroidglandaftertotalthyroidectomy，shortenrecoverytimeofparathyroidglandtimeaftersurgery，andimprove hypocalcemiasymptoms，withsignificantcurativeeffect.