Abstract：Objective：To observe the effect of transcutaneous electrical point stimulation and total intravenous anesthesia on intraoperative entropy index of patients who underwent ureteroscopy. Methods： A total of 62 cases of patients who underwent ureteroscopy were selected and randomly divided into two groups. Before anesthesia，the observation group was given transcutaneous electrical point stimulation at Shenyu point(BL 23) at both sides for 30 minutes，and the electrodes were applied without electrical stimulation at the same points in the control group. In the two groups，the operation was performed under conventional total intravenous anesthesia. Intraoperative entropy index，heart rate(HR)，mean arterial pressure(MAP)， the time for recovery from anesthesia，postoperative scores of Visual Analogue Scale(VAS) and incidence of adverse reactions were compared between the two groups. Results：Compared with that in the control group，in the observation group，the state entropy(SE) was lower when the ureteroscope entered the bladder(T2) and ureteroscope entered the ureteral orifice(T3) (P＜0.05)； the difference between reaction entropy and state entropy(RE- SE)， HR， MAP in the observation group were lower at T2，T3 and anesthesia recovery(T4)(P＜0.05)；the number of intraoperative physical responses，postoperative VAS score and the overall incidence of adverse reactions in the observation group were lower(P＜0.05). Conclusion： During ureteroscopy， the application of transcutaneous electrical point stimulation and total intravenous anesthesia can reduce intraoperative electroencephalographic entropy index，and achieve better anesthetic and analgesic outcomes.