Abstract：The pathogenesis of pulmonary fibrosis is generally the deficiency in root and excess in tip，and lung vessels stasis is the main pathological mechanism that promotes the progression of pulmonary fibrosis. Through the analysis and summary of the experimental studies on the treatment of pulmonary fibrosis with insect medicines in recent years and the combination with clinical practice， it is found that the single drug treatment including leech， earth- worm， roach， giant gecko，centipede，snake and Chinese caterpillar fungus，or complex prescription of two or more insect medicines are the most commonly used. Insect medicines play an important role in reducing fibrin deposition， alleviating inflammatory cells infiltration， inhibiting fibroblast growth and improving pulmonary vascular remodeling. For the treatment of pulmonary fibrosis，insect medicines have a good application prospect and deserve further in-depth study.