Abstract：Objective：To observe the effect of Chinese medicine intervention combined with early rehabilitation care on activities of daily living and neurological function in stroke patients. Methods： A total of 140 cases of stroke patients were divided into the control group and the observation group according to the random number table method， 70 cases in each group. Both groups were given routine treatment；the control group was given early rehabilitation care，and the observation group was additionally given Chinese medicine intervention based on the treatment of the control group. The scores of National Institutes of Health Stroke Scale(NIHSS)，Activities of Daily Living Scale(ADL) and Glasgow Coma Scale(GCS) in the two groups were compared，and the nutrition indicators as well as anxiety and depression were evaluated. Results：Before treatment，there was no significant difference being found in the comparison of the scores of NIHSS，ADL and GCS between the two groups(P＞0.05). After treatment，the NIHSS scores in the two groups were decreased when compared with those before treatment， and the scores of ADL and GCS were increased(P＜0.05)； the scores of NIHSS， ADL and GCS in the observation group were significantly better than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the body mass index(BMI)，albumin(Alb) and prealbumin(PA) between the two groups(P＞0.05). After treatment， BMI， PA and Alb in the control group were decreased when compared with those before treatment，and BMI，PA and Alb in the observation group were significantly better than those in the control group(P＜0.05). After treatment， the proportions of mild depression and mild anxiety in the observation group were significantly higher than those in the control group， and the proportions of major depression and major depression were significantly lower than those in the control group(P＜0.05). Conclusion：Chinese medicine intervention combined with early rehabilitation care for stroke patients has significant effect，which can improve quality of life and neurological function，and relieve anxiety and depression.