Abstract：Objective：To observe the clinical effect of integrated Chinese and western medicine combined with medical and nursing measures for patients with IgA nephropathy of qi-yin deficiency type. Methods：A total of 85 cases of patients with IgA nephropathy were selected as the study objects，and were divided into the observation group and the control group according to the random number table method，45 and 40 cases in each group respectively. Both groups were intervened with routine treatment of modern medicine and symptomatic nursing measures，and the observation group was additionally given comprehensive medical and nusing measures of Chinese medicine. The period of both treatment and nursing was four weeks. Before intervention and after four-week intervention，the indexes of the kidney function，routine urine examination， and immune function were detected；patients' command of health knowledge，nursing compliance，and nursing satisfaction were studied. The clinical effect was compared between the two groups. Results：After various kinds of intervention，the total clinical effective rate was 93.33% in the observation group， and 72.50% in the control group， the difference being significant between the two groups(P＜0.05). Levels of serum creatinine and 24- hour urine protein quantification as well as urinary albumin/creatinine ratio in the two groups were decreased when compared with those before intervention(P＜0.05)， and glomerular filtration rate was increased when compared with that before intervention(P＜0.05). Levels of serum creatinine and 24- hour urine protein quantification as well as urinary albumin/creatinine ratio in the observation group were lower than those in the control group(P＜0.05)，and glomerular filtration rate was higher than that in the control(P＜0.05). Levels of CD4+ and CD4+/CD8+ in the two groups were decreased when compared with those before intervention(P＜0.05)，and level of CD8+ was increased when compared with that before intervention(P＜0.05). Levels of CD4+ and CD4+/CD8+ in the observation group were lower than those in the control group(P＜0.05)，and level of CD8+ was higher than that in the control(P＜0.05). Scores of command of health knowledge and nursing satisfaction in the observation group were higher than those in the control group， and the total rate of nursing compliance was higher than that in the control group(P＜0.05). Conclusion： Comprehensive medical and nursing measures of Chinese medicine based on routine medical and nursing measures of modern medicine has a satisfactory curative effect on patients with IgA nephropathy，which conduces to improving the kidney function，enhancing immune function of body， and increase degree of command of health knowledge， nursing compliance， and nursing satisfaction.