基于DTI 技术探讨廉泉、天容可视化齐刺治疗环咽肌功能障碍所致吞咽困难的中枢效应机制
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R766;R246

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福建中医药大学临床专项校管课题(XB2017070)


Exploration of Central Effect Mechanism of Visual Triple Needling at Lianquan and Tianrong for Dysphagia Caused by Cricopharyngeal Dysfunction Based on DTI Technology
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    摘要:

    目的:观察廉泉、天容可视化齐刺治疗环咽肌功能障碍(CD)所致吞咽困难的临床疗效,并基于弥散张量成像(DTI)技术从脑白质纤维束结构与密度的改变探讨其可能的作用机制。方法:选取168 例CD 所致吞咽困难患者,按随机数字表法分为观察组和对照组,每组84 例。观察组给予廉泉、天容可视化齐刺治疗,并在每侧的夹廉泉及天容旁连接电针;对照组给予常规针刺治疗。2 组均治疗4 周。比较2 组治疗前后吞咽造影检查(VFSS)评分、舌骨喉复合体动度及患侧脑区各向异性分数(FA),比较2 组临床疗效。结果:治疗后,2 组VFSS 评分均较治疗前升高(P<0.01),观察组VFSS 评分高于对照组(P<0.01)。治疗后,2 组舌骨上移、舌骨前移、甲状软骨上移、甲状软骨前移距离均较治疗前增大(P<0.05);观察组舌骨上移、舌骨前移、甲状软骨上移、甲状软骨前移距离均大于对照组(P<0.05)。治疗后,2 组患侧小脑下脚、小脑中脚、小脑上脚、大脑脚、脑桥束、皮质核束FA 值均较治疗前增大(P<0.05),观察组患侧脑区上述6 项FA 值均大于对照组(P<0.05)。观察组总有效率为97.6%,高于对照组的89.3%,差异有统计学意义(P<0.05)。结论:廉泉、天容可视化齐刺可改善CD 所致吞咽困难患者的临床症状,其作用机制可能是相关脑区白质纤维束的结构及密度改变增强了其神经可塑性。

    Abstract:

    Abstract:Objective:To observe the clinical effect of visual triple needling at Lianquan(CV 23) and Tianrong(SI 17) points for dysphagia caused by cricopharyngeal dysfunction(CD), and to explore its possible mechanism of the changes of the structure and density of white matter fiber tracts based on diffusion tensor imaging(DTI) technology. Methods: A total of 168 cases of patients with dysphagia caused by CD were divided into the observation group and the control group according to the random number table method, 84 cases in each group. The observation group was given visual triple needling at Lianquan(CV 23) and Tianrong(SI 17) points,and electroacupuncture was connected next to Jialianquan and Tianrong on each side;the control group was given routine acupuncture treatment. Both groups were treated for four weeks. Before and after treatment,the Videofluoroscopic Swallowing Study(VFSS) scores,the mobility of hyoid-larynx complex and the FA values of each cerebral area in the injured side in the two groups were compared. The clinical effect in the two groups was compared. Results:After treatment,the VFSS scores in the two groups were increased when compared with those before treatment(P<0.01),and the VFSS score in the observation group was higher than that in the control group(P<0.01). After treatment,the upward displacement and antelocation of hyoid bone as well as the upward displacement and antelocation of thyroid cartilage in the two groups were increased when compared with those before treatment(P<0.05); the upward displacement and antelocation of hyoid bone as well as the upward displacement and antelocation of thyroid cartilage in the observation group were larger than those in the control group(P<0.05). After treatment, the FA values of pedunculus cerebellaris inferior,pedunculus cerebellaris medius,pedunculus cerebellaris superior,pedunculus cerebri,corticopontine tract and corticonuclear tract in the injured side in the two groups were increased when compared with those before treatment(P<0.05),and the above FA values of each cerebral area in the injured side in the observation group were larger than those in the control group(P<0.05). The total effective rate was 97.6% in the observation group, higher than that of 89.3% in the control group,the difference being significant(P<0.05). Conclusion:The visual triple needling at Lianquan and Tianrong points for dysphagia caused by CD can improve the clinical symptoms of patients,whose mechanism may be the changes of the structure and density of related white matter fiber tracts hence strengthening its neural plasticity.

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金海鹏,李相良,王永,叶清景,莫映楠.基于DTI 技术探讨廉泉、天容可视化齐刺治疗环咽肌功能障碍所致吞咽困难的中枢效应机制[J].新中医,2021,53(11):136-140

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  • 在线发布日期: 2021-06-10
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