茵栀黄颗粒联合光疗干预新生儿病理性黄疸临床研究
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R722.17

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Clinical Study on Yinzhihuang Granules Combined with Phototherapy Intervening Pathological Jaundice in Newborns
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    摘要:

    目的:观察茵栀黄颗粒联合光疗干预新生儿病理性黄疸的临床疗效。方法:将192 例新生儿病理性黄疸患儿随机分为对照组与试验组各96 例。对照组给予光疗干预,试验组在对照组的基础上给予茵栀黄颗粒治疗。治疗后比较2 组血清总胆红素水平、退黄时间、临床疗效及治疗安全性。结果:试验组总有效率为95.83%,对照组为84.38%,2 组比较,差异有统计学意义(P<0.05)。治疗前,2 组血清总胆红素水平比较,差异无统计学意义(P>0.05)。治疗3 d、5 d、7 d,2 组血清总胆红素水平均较治疗前降低(P<0.05),且试验组各时间点的血清总胆红素水平均低于对照组(P<0.05)。试验组退黄时间短于对照组,差异有统计学意义(P<0.05)。试验组不良反应发生率为3.13%,对照组为12.50%,2 组比较,差异有统计学意义(P<0.05)。结论:茵栀黄颗粒联合光疗干预新生儿病理性黄疸疗效显著,能快速降低血清总胆红素水平,缩短退黄时间,且不良反应较少。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Yinzhihuang granules combined with phototherapy intervening pathological jaundice in newborns. Methods: A total of 192 cases of newborns with pathological jaundice were randomly divided into the control group and the experiment group, 96 cases in each group. The control group was intervened with phototherapy,and the experiment group was additionally treated with Yinzhihuang granules based on the treatment of the control group.After treatment,the levels of total bilirubin in serum,the time of clearing jaundice,the clinical effect and the safety in the two groups were compared. Results:The total effective rate was 95.83% in the experiment group and 84.38% in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of total bilirubin in serum between the two groups(P>0.05).After treatment for three,five and seven days respectively,the levels of total bilirubin in serum in the two groups were decreased when compared with those before treatment(P<0.05), and the levels at each time point in the experiment group were lower than those in the control group(P<0.05). The time of clearing jaundice in the experiment group was shorter than that in the control group,the difference being significant(P<0.05). The incidence of adverse reactions was 3.13% in the experiment group and 12.50% in the control group,the difference being significant(P<0.05). Conclusion:Yinzhihuang granules combined with phototherapy has significant curative effect on pathological jaundice in newborns,which can quickly reduce the levels of total bilirubin in serum,and shorten the time of clearing jaundice,withfewer adverse reactions.

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潘锦艳.茵栀黄颗粒联合光疗干预新生儿病理性黄疸临床研究[J].新中医,2021,53(11):159-161

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  • 在线发布日期: 2021-06-10
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