Abstract：Objective：To observe the clinical effect of modified Gegen Qinlian tang in the treatment of newly-diagnosed type 2 diabetes mellitus(T2DM) with syndrome of binding of phlegm and(dampness) heat，and its effect on adipocytokines. Methods：A total of 100 cases of patients with newly-diagnosed T2DM were randomly divided into the observation group and the control group，50 cases in each group. The control group was given oral administration of metformin hydrochloride tablets taken with food，the observation group was additionally treated with modified Gegen Qinlian tang based on the treatment of the control group. Both groups were treated for three months. Before and after treatment， levels of fasting blood glucose (FBG)， postprandial 2 h blood glucose(P2hBG)， hemoglobin A1c(HbA1c)， and fasting insulin(FINS)， homeostatic model assessment of insulin resistance(HOMA- IR)， insulin sensitivity index(InISI)， homeostasis model assessment of β- cell function(HOMA-β) were detected in the two groups. After treatment，the standard-reaching rates of FBG and HbA1c were counted. Before and after treatment， levels of total cholesterol(TC)， triglyceride(TG)， high- density lipoprotein cholesterol (HDL- C)，and low- density lipoprotein cholesterol(LDL- C) were detected；levels of adipocytokines，such as adiponectin， resistin and leptin， were detected； the score of the syndrome of binding of phlegm and(dampness) heat was recorded. Results： After treatment， when compared with those in the same group before treatment， levels of FBG， P2hBG， HbA1c， HOMA- IR， TC， TG， LDL- C， leptin， resistin as well as the score of the syndrome of binding of phlegm and (dampness) heat in the two groups were decreased(P＜0.01)， and the levels of FINS， HOMA- β， InISI， HDL- C， and adiponectin were increased(P＜0.01). After treatment， when compared with those in the control group， levels of FBG， PBG，HbA1c，HOMA-IR，TC，TG，LDL-C，leptin，resistin，as well as the score of the syndrome of binding of phlegm and(dampness) heat in the observation group were lower(P＜0.01)， and the levels of FINS， HOMA- β， InISI， HDL- C， adiponectin， and the compliance rate of HbA1c were higher(P＜0.01， P＜0.05). Conclusion： In the treatment of patients with newly- diagnosed T2DM with syndrome of binding of phlegm and(dampness) heat，the oral administration of modified Gegen Qinlian tang based on metformin hydrochloride tablets，can regulate glucose and lipid metabolism，improve clinical symptoms， enhance the compliance rate of HbA1c， reduce glucotoxicity and lipotoxicity； it can regulate adipocytokines， improve insulin resistance，enhance insulin sensitivity and islet β cell function while controlling blood glucose.