Abstract： Objective： To observe the clinical effect of knee arthralgia prescription for patients with knee osteoarthritis. Methods： A total of 76 cases of patients with knee osteoarthritis were randomly divided into the control group and the treatment group， 38 cases in each group. The control group was treated with celecoxib， and the treatment group was treated with knee arthralgia prescription. After four- week treatment， the clinical effect in the two groups was observed. Before and after treatment，the changes in perimeters as well as flexion and extension activity in the knee joint in the two groups were compared and analyzed. Results：The total effective rate was 97.37% in the treatment group and 86.84% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of perimeters as well as flexion and extension activity in the knee joint between the two groups(P＞0.05)； after treatment， the perimeters in the knee joint in the two groups were decreased when compared with those before treatment(P＜0.05)，the flexion and extension activity in the knee joint was increased(P＜0.05)，and the improvement of the above two indexes in the treatment group was better than that in the control group(P＜0.05). Conclusion： Knee arthralgia prescription for knee osteoarthritis has definite curative effect，whose effect is better than that of celecoxib.